Amitriptyline
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3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,
N-dimethyl-1-propanamine
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CAS number
549-18-8
| ATC code
N06AA09
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| Chemical formula
| C20H23N
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| Molecular weight
| 277.403 g/mol
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| Bioavailability
| 40%
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| Metabolism
| Hepatic
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| Elimination half-life
| 12-24 hours
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| Excretion
| Renal
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| Pregnancy category
| ?
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| Legal status
| ?
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| Routes of administration
| Oral
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Amitriptyline hydrochloride is an antidepressant drug from the tricyclic antidepressant group, which is sold under the trade names Elavil®, Tryptanol® or Endep®.
It is a white, odorless, crystalline compound which is freely soluble in water. It is usually dispensed in tablet form. The empirical formula of its hydrochloride salt is C20H23N·HCl.
Contents
- 1 Mechanism of Action
- 2 Uses
- 2.1 Approved
- 2.2 Unapproved/Off-Label/Investigational
- 3 See also
- 4 References
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Mechanism of Action
Amitriptyline affects serotonin and noradrenaline reuptake almost equally.
Uses
Approved
Amitriptyline is approved for the treatment of endogenous depression and involutional melancholia (depression of late life, which is no longer seen as a disease in its own right),[1] and reactive depression and for depression secondary to alcoholism and schizophrenia.
Unapproved/Off-Label/Investigational
Amitriptyline may be prescribed for other conditions such chronic pain or fibromyalgia.
A randomized controlled trial published in June of 2005 found that amitriptyline was effective in functional dyspepsia refractory to famotidine and mosapride combination therapy.[2]
See also
- antidepressant
- tricyclic antidepressant
References
- PubChem Substance Summary: Amitriptyline National Center for Biotechnology Information.
- TREPILINE®-10 TABLETS; TREPILINE®-25 TABLETS South African Electronic Package Inserts. 12 May 1978. Revised February 2004.
- SAROTEN® RETARD 25 mg Capsules; SAROTEN® RETARD 50 mg Capsules South African Electronic Package Inserts. December 1987. Updated May 2000.
- ^ Weissman MM. "The myth of involutional melancholia." Journal of the American Medical Association. 1979 Aug 24-31;242(8):742-4. PMID 459064
- ^ Otaka M, Jin M, Odashima M, Matsuhashi T, Wada I, Horikawa Y, Komatsu K, Ohba R, Oyake J, Hatakeyama N, Watanabe S. "New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline." Alimentary Pharmacology & Therapeutics. 2005 Jun;21 Suppl 2:42-6. PMID 15943846 Fulltext
| Antidepressants edit
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| Dopamine reuptake inhibitors edit
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{Bupropion}
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| Norepinephrine reuptake inhibitors edit
|
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{Atomoxetine}
{Reboxetine}
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| Monoamine oxidase inhibitors edit
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{Ayahuasca}
{Nialamide}
{Selegiline}
{Isocarboxazid}
{Iproniazide}
{Iproclozide}
{Moclobemide}
{Phenelzine}
{Toloxatone}
{Tranylcypromine}
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| Selective serotonin reuptake inhibitors edit
|
|
{Alaproclate}
{Etoperidone}
{Citalopram}
{Escitalopram oxalate}
{Fluoxetine}
{Fluvoxamine maleate}
{Paroxetine}
{Sertraline}
{Zimelidine}
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|
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Serotonin-norepinephrine reuptake inhibitors edit
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{Desipramine}
{Duloxetine}
{Milnacipran}
{Nefazodone}
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| Bicyclic antidepressants edit
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{Viloxazine}
{Venlafaxine}
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| Tetracyclic antidepressants [ edit ]
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{Maprotiline}
{Mianserin}
{Mirtazapine}
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| Selective serotonin reuptake enhancers edit
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{Tianeptine}
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| Tricyclic antidepressants [ edit ]
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{Amitriptyline}
{Amoxapine}
{Clomipramine}
{Desipramine}
{Dothiepin}
{Doxepin}
{Imipramine}
{Lofepramine}
{Nortriptyline}
{Protriptyline}
{Trimipramine}
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ru:Амитриптилин
Categories: Tricyclic antidepressants | Analgesics
